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A Role for Copper in the Toxicity of Zinc-Deficient Superoxide Dismutase to Motor Neurons in Amyotrophic Lateral Sclerosis

In the breast cancer setting, Doxil remains an off-label use, while in Europe a non-PEGylated formulation has been approved by the EMA (i.e., Myocet) [99]

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182 The senescence and exhaustion of HSCs are the core reasons for the decline in hematopoietic system function, involving multiple mechanisms such as telomere attrition, oxidative stress, inflammatory disorders and epigenetic disorders, which ultimately lead to anemia, immunodeficiency, and an increased risk of hematological diseases

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